Past Seminar Series: 2009-2010
Craig S. Atwood, Ph.D. and Sivan Vadakkadath Meethal, Ph.D.
Title: "Progestins: Obligatory Developmental Functions from Embryogenesis through to the Adult Brain" and "Molecular Basis of Aging: A Glimpse from the C. elegans Biography"
Catherine Auger, Ph.D.
Title: "Progesterone Action in the Male Brain"
Cynthia Carlsson, M.D., M.S.
Title: "Cerebrospinal Fluid Biomarkers in Middle-Aged Adults with Parental History of Alzheimer's Disease: New Data from the ESPRIT Trial"
Albee Messing, VMD, Ph.D. and Tracy Hagemann, Ph.D.
Title: "Astrocytes as Instigators of NeuroDegeneration: The Alexander Disease Experience."
Luigi Puglielli, MD, Ph.D. and Mariana Pehar, Ph.D.
Title: "Regulation of the ER-Based Acetylation Machinery by Ceramide and the Unfolded Protein Response."
Jerry Yin, Ph.D.
Title: "Flies and Sleep"
Ian Duncan, BVMS, Ph.D.
Title: FRSE and Chelsey Smith, B.S. "Myelin Disease and its Dellular Consequences."
Katherine Kalil, Ph.D. and Li Li, Ph.D. candidate
Title: "Wnt Signaling in Cortical Axon Outgrowth and Guidance."
Past Seminar Series: 2008-2009
October 7th: Luigi Puglielli Laboratory
Luigi Puglielli, M.D., Ph.D.
Title: "The aging program and Alzheimer's disease"
Mi Hee Ko, Ph.D.
Title: "Two ER/ERGIC-based lysine acetyltransferases post-translationally regulate BACE1 levels"
November 4th: Lingjun Li Laboratory
Title: "Exploring Neuropeptidomes via Novel Mass Spectral Techniques"
Title: "Comparative Analysis of Neuropeptides in Food Intake and Environmental Stress by a Multi-faceted Mass Spectrometric Approach"
December 9th: Anthony P Auger, Ph.D.,
Title: "How to Build a Male Brain: A Role for Steroid Receptors and the Social Environment"
January 6th: Erik Dent, Ph.D.,
Title: "From Cradle to Grave: Microtubule Dynamics from Neurite Outgrowth to Dendritic Spine Plasticity"
February 3rd: Cara Westmark, Ph.D. and Jim Malter, M.D.,
Title: "The Dysregulation of Amyloid Precursor Protein in Alzheimer's Disease, Fragile X Syndrome & Down Syndrome"
March 3rd: No Speaker
April 7th: Raghu Vemuganti, Ph.D. and Yiping Yan, Ph.D.,
Title: "Role of MicroRNAs inIschemic Brain Damage"
May 5th: Qiang Chang, Ph.D.,
Title: "Generating iPS Cells from RTT Patient Fibroblasts"
June 2nd: Nansi Jo Colley, Ph.D.,
Title: "Neurodegeneration from the Eye of the Fly"
Past Seminar Series: 2007-2008
September 4th: Avtar Roopa, Ph.D. "Metabolic regulation of neuronal gene expression in epilepsy and cancer"
October 2nd: Brad Postle, Ph.D. "Using repetitive transcranial magnetic stimulation to study working memory"
November 6th: Ben Campbell, Ph.D."Hormones and aging"
December 4th: Erik Dent, Ph.D. "Cytoskeletal-associated-proteins andthe nervous system"
January 8th: Dengshun Wang, MD, Ph.D. "Abeta-degrading Enzymes and Alzheimer's Disease"
February 5th: Corinna Burger, Ph.D. "Strategies to generate Animal Models for neurodegenerative disordersusing recombinant Adeno-associated virus"
March 4th: Anita Bhattacharyya, Ph.D. "Down syndrome and Alzheimer's Disease"
April 1st: Cynthia Carlsson, M.D., M.S. "Cholesterol and Alzheimer's Disease"
May 6th: Luigi Puglielli, M.D., Ph.D. "p44 and APP: synergistic regulation of the aging program?"
June 3rd: Peter Lipton, Ph.D., "Leaky lysosomes cause stroke damage"
Past Seminar Series: 2006-2007
September 5th: Rao Adibhatla, M.D., "Cytokines, Lipid Metabolism, and
CDP-choline in Stroke" and James Hatcher: "Loss of cellular
phosphatidylcholine: a cause or a result of cell death?"
October 3th: Craig Atwood, Ph.D., Department of Medicine
November 7st: Dandan Sun, M.D., Ph.D., Department of Neuroscience
December 5th: Jonathon Levenson, Ph.D., Department of Neuroscience
January 9th: Cindy Carlsson, M.D., Department of Medicine; "Regional
Brain Perfusion on MRI in Persons at Risk for Alzheimer's Disease"
February 6th: Peter Lipton, Ph.D., Department of Neuroscience
March 6th: Sterling Johnson, Ph.D., Department of Medicine
April 3rd: Luigi Puglielli, M.D., Ph.D., Department of Medicine
May 1st: Dengshun Wang, M.D., Ph.D., Department of Pathology and
Laboratory Medicine; "A-beta degradation and AD" and "Biological
significance of Pin1 in AD pathogenesis"
June 5th: SPECIAL PRESENTATION
Ryan Haasl, M.A., Department of Medicine; "The importance of gene-gene interactions in the assessment of Alzheimer's disease risk"
Prashob Porayette, M.B. B.S., Department of Medicine; "Clues from developmental biology as to the function of the amyloid precursor protein"
Past Seminar Series: 2005-2006
September 6th: Craig Atwood laboratory
Speaker 1: Craig Atwood, Ph.D., Assistant Professor of Medicine
Topic 1: 'Does luteinizing hormone have a novel autocrine function in the brain?'
Speaker 2: Tianbing Liu, M. Sc.
Topic 2: 'Presence of luteinizing hormone receptor in the brain and regulation of its expression by hormones of the HPG axis.'
October 4th: Sterling Johnson laboratory
Speaker 1: Sterling Johnson, Ph.D., Assistant Professor of Medicine
Topic 1: 'Functional and structural brain imaging studies in people at risk for Alzheimer's Disease. Overview and Recent findings: The hippocampal response in middle aged adults with risk factors for AD.'
Speaker 2: Mehul Trivedi, Ph.D.
Topic 2: 'Voxel-based morphometry discriminates mild cognitive impairment from controls.'
Speaker 3: Michele Ries, Ph.D.
Topic 3: 'The posterior cingulate and risk for AD: Task-dependent posterior cingulate activation in mild cognitive impairment.'
November 1st: Clive Svendson laboratory
Speaker 1: Clive Svendsen, Ph.D., Professor of Medicine
Topic 1: 'Growth factors and stem cells for the treatment of neurodegenerative diseases.'
Speaker 2: Allison Ebert, Ph.D.
Topic 2: 'How the degenerative state of the brain dictates how stem cells survive and integrate.'
November 2nd: SPECIAL PRESENTATION (as part of the Pathology and Laboratory Medicine Training Program)
Speaker: Karl Herrup, M.D.
Department of Neuroscience
Case School of Medicine
Topic: 'Paved with good intention: Cell cycle events and neurodegenerative disease.'
December 6th: Luigi Puglielli laboratory
Speaker 1: Claudio Constantini, Ph.D., Research Associate
Topic 1: 'Aging as a risk factor for Alzheimer's disease: in search for a molecular explanation.'
January 10th: Sanjay Asthana laboratory
Speaker 1: Carey Gleason, Ph.D., Assistant Scientist
Topic 1: 'Alzheimer's Disease Center Grant Overview.'
February 7th: James Malter laboratory
Speaker 1: Cara Westmark, Ph.D., Assistant Scientist
Topic 1: 'A Role for Amyloid Precursor Protein in Fragile X Syndrome: molecular aspects.'
Topic 2: 'A Role for Amyloid Precursor Protein in Fragile X Syndrome: new transgenic models?'
March 7th: Jerry Yin laboratory
Speaker 1: Jerry Yin, Ph.D. Professor of Genetics
Topic 1: 'Speculations on CREB as a neuronal thermostat in function and dysfunction.'
April 4th: Cynthia Carlsson laboratory
Speaker 1: Cynthia Carlsson, M.D., M.S., Assistant Professor of Medicine
Topic 1: 'The effects of statins and APOE4 genotype on cognitive outcomes in presymptomatic adults at risk for Alzheimer's disease.'
Topic 2: 'The relationship between CSF and MRI biomarkers in persons at risk for Alzheimer's disease.'
May 2nd: Luigi Puglielli laboratory
Speaker 1: Mary Cabell Jonas
Topic 1: 'A novel form of post-translational modification and its role in the maturation of BACE1.'
Speaker 2: Mi Hee Ko, PhD
Topic 2: 'The transcriptional activity of the sterol carrier protein (SCP-x/pro-SCP-2) gene is regulated through post-translational competition of its own products.'
June 6th: SPECIAL PRESENTATION
Speaker: Pankaj D. Mehta, Ph.D.
Department of Immunology
New York State Institute for Basic Research in Developmental Disabilities.
Topic: 'Biomarkers of Alzheimer disease.'
Past Seminar Series: 2004-2005
September 7th: Craig Atwood laboratory
Speaker 1: Craig S. Atwood, Ph.D., Assistant Professor of Medicine
Topic 1: Introduction to the Series
Topic 2: 'The role of the HPG axis in aging and Alzheimer's disease.'
Speaker 2: Tianbing Liu, M.Sc.
Topic 3: 'Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression.'
October 5th: Sterling Johnson laboratory
Speaker 1: Sterling Johnson, Ph.D. Assistant Professor of Medicine
Topic 1: 'Functional brain imaging of memory: Application to early detection of Alzheimer's disease.'
Speaker 2: Mehul Trivedi, Ph.D., Research Associate
Topic 2: 'APOE and gender effects on hippocampal activation in persons at risk for AD.'
November 2nd: Luigi Puglielli laboratory
Speaker 1: Luigi Puglielli, M.D., Ph.D., Assistant Professor of Medicine
Speaker 2: Claudio Costantini, Ph.D., Research Associate
Topic: 'The TrkA/p75NTR receptor system: a molecular link between aging and Alzheimer's disease.'
December 7th: Jeffrey Johnson laboratory
Speaker 1: Jeffery Johnson, Ph.D., Assistant Professor of Pharmacology
Topic 1: 'Understanding the fragments of the amyloid precursor protein: Someplace between chaos and clarity.'
Speaker 2: Julie Kern, Ph.D.
Topic 2: 'A role for the Nr2-ARE pathway in slowing the progress of ALS.'
January 11th: James Malter laboratory
James Malter, M.D. - Introduction
Speaker 1: Pam Westmark, Ph.D.
Topic 1: 'Functional analysis of the 52 base stop element (sce) in APP mRNA.'
Speaker 2: Oleg Broytman
Topic 2: 'Identification and purification of 52 base sce binding proteins.'
February 8th: Sanjay Asthana laboratory
Speaker 1: Carey Gleason, Ph.D., Assistant Scientist
Topic 1: 'Treating memory loss: Potential of soy isoflavones and other natural therapies.'
March 1st: Mark Sagar laboratory
Speaker 1: Mark Sager, M.D., Professor of Medicine, Director, Wisconsin Alzheimer's Institute
Topic 1: 'Wisconsin Registry for Alzheimer's Prevention: Studies of pre-clinical AD.'
April 5th: Jyoti Watters laboratory
Speaker 1: Jyoti J. Watters, Ph.D., Assistant Professor
Topic 1: 'Estrogen inhibition of microglial functions: potential mechanism of neuroprotection.'
Topic 2: 'Adenine nucleotide modulation of microglial inflammatory capacity.'
April 19th SPECIAL PRESENTATION
Speaker: D. Allan Butterfield, Ph.D.
The Alumni Professor of Biological and Physical Chemistry
Director, Center of Membrane Sciences
Biophysical Chemistry and Neurochemistry
University of Kentucky
Topic: 'Oxidative stress and neurodegeneration in Alzheimer's disease brain: Central role of amyloid §-peptide.'
May 3rd: SPECIAL PRESENTATION
Speaker: Xudong Huang, Ph.D.
Massachusetts General Institute for Neurodegenerative Disease
Massachusetts General Hospital and Harvard Medical School
Topic: 'Metallobiochemistry of Alzheimer's disease and its "Theranostic" implications.'
May 11th: SPECIAL PRESENTATION (as part of the Pathology and Laboratory Medicine Training Program)
Speaker: Mark A. Smith, Ph.D.
Department of Pathology
Case Western Reserve University
Topic: 'Alzheimer disease: Facts, fictions and the two hit hypothesis.'
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